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Max focuses on making the hospital better and on his wife's condition while ignoring his own medical issues. Frome and Kapoor sue a school district over a young boy's psychiatric medication.

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When Max volunteers New Amsterdam to take over for a short-staffed hospital nearby, things get chaotic quickly. Iggy has a crisis of conscience after receiving the news that funding for a garden has been granted and an eager resident learns a secret about Dr. Bloom.

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A patient's treatment plan takes an unexpected turn when Max gets overly invested. Meanwhile, Reynolds celebrates his birthday with some help from the hospital and Kapoor grapples with a case that hits close to home.

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Reynolds confronts a difficult episode from his past. Max distracts himself from chemotherapy by taking on the case of a frequent-flyer patient. Frome helps a young man suffering from severe delusions. Sharpe worries about Bloom's attempt to detox.

Tensions are high in the hospital as Bloom is overruled on a diagnosis. Meanwhile, Iggy notices that something may be amiss with one of the hospital's most respected surgeons.

Max (Ryan Eggold) continues to work to solve underlying problems within the hospital despite his continuing struggles with treatment. Meanwhile, Reynolds (Jocko Sims) makes the choice to do a costly surgery to determine an elusive diagnosis and Bloom (Janet Montgomery) must face her personal demons head-on.

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Max bonds with the patients undergoing chemo with him, but a conversation leads him to struggle with his reality. Meanwhile, Reynolds has difficulty handling a personal matter regarding a patient's family and Iggy struggles with a realization regarding his daughter.

When a history-making blizzard hits New York, Max and his staff must work together to keep the patients safe with few resources, even if it means taking to the streets of the city and braving the storm.

As the doctors continue to weather the storm without power, Max relies on an unlikely source to get the lights back on. Reynolds must get creative as he continues to work to save Hugh with very few resources.

Reynolds struggles to help a young cystic fibrosis patient with curious symptoms. Kapoor finally comes face-to-face with Ella after their awkward encounter. Sharpe takes a major step in her personal life.

When an NYPD officer is hit by a car in the line of duty, the hospital is turned upside down to save her. Kapoor and Iggy work with a patient struggling with a previous surgery.

Max is forced to reckon with his diagnosis in a new way as things become more difficult for him; Reynolds is forced to address what could have gone wrong in a recent surgery.

Max goes head-to-head with hospital administration when he comes up with a new plan for patients without insurance. Iggy struggles with an accusation brought against him. Sharpe navigates her role as deputy medical director.

Sharpe works on a creative way to help Max. Kapoor gets surprising news. Reynolds takes a big step in his relationship with Evie. one of the doctors makes a life-altering decision.